HERA
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Project HERA

Changelog

Every update to the HERA engine, newest first.

12 updates
06 Jul 2026 build 2026.07.06
Release
+Build 2026.07.06 Cleaner submissions, clearer evidence review, and a better view of the full pipeline. This update adds canonical HGVS handling on submission, a rebuilt Applied Criteria panel, faster ClinVar matching, and a new Stats page comparing HERA with V2

HGVS Sanitisation: Delins variants written with explicit deleted bases, such as delGGTGGinsTGTGC, are now normalised to canonical HGVS before submission. The deleted bases are checked against the reference first, and variants where the deleted sequence length does not match the coordinates are flagged for review instead of being auto-corrected.

  • Applied Criteria, rebuilt: The panel now starts with the codes that fired, shown as full cards with the finding, strength pips, a legend, and linked evidence. Assessed but unmet codes are shown in a ruled pathogenic and benign grid, so reviewers can quickly see why each code did or did not apply without opening extra sections. The layout works the same across Tavtigian points and categorical ACMG combining.
  • Faster ClinVar lookups: Variants are now matched directly to their exact ClinVar record when possible, with gene-level search as a fallback and the older search method used only as a last resort. This removes the search then verify step that could occasionally lead to the wrong match. Classification, review status, and star rating now come directly from the matched record, with page details and screenshots used as secondary confirmation.
  • Pipeline Analytics: A new Stats page tracks run volume, success rate, median turnaround, and daily submission trends with a fitted growth line. It also includes a launch-date-normalised comparison of HERA and V2, looking at throughput per active day, early adoption, and per-gene classification breakdowns with a counts and share toggle.
24 Jun 2026 build 2026.06.24
Feature
+Pipeline Rerun Old variant pages can now be re-run when the interpretation pipeline is updated

When a new change is made to the variant interpretation pipeline, older variant pages now show a rerun option

  • Each rerun consumes a free hera slot or a code slot
24 Jun 2026 build 2026.06.24
Feature
+Worker Status Added a clear indicator when workers are down, preventing submission of new variants

A visible status indicator now appears when pipeline workers are unavailable

  • New variant submissions are blocked while workers are down to prevent failed runs
  • Submission becomes available again automatically once workers recover
24 Jun 2026 build 2026.06.24
Feature
+Rerun History View historical entries for variants that have been re-run

Variant pages now display a history of previous interpretation entries for re-run variants

  • Compare prior and current results across reruns
24 Jun 2026 build 2026.06.24
Feature
+Gene Diagram Added ability to filter the gene diagram view by variant consequence

Views in the gene diagram can now be filtered based on variant consequence

  • Focus the diagram on relevant consequence types (e.g. missense, synonymous, splice)
17 Jun 2026 build 2026.06.17
Fix
✓gnomAD Canada errors with API calls fixed. Monitoring for issues
17 Jun 2026 build 2026.06.17
Feature
+Literature Review Upgraded literature review to provide auditable trail of how paper was processed

Papers that are reviewed for the interpretation now provide details on why and how it was used

  • Will now specify whether specific variant was found and search terms
  • Entries will provide direct quotes and references within the paper when available
04 Jun 2026 build 2026.06.04
Feature
+Introducing the Changelog — track every update to HERA

HERA now keeps a running history of updates, so you can see what's changed and when.

  • A dedicated changelog page lists the full history, newest first
  • A live update band on the home page rotates through the three most recent changes
  • Each entry is dated and categorised as a feature, data, or fix update
02 Jun 2026 build 2026.06.02
Feature
+New Browse variants view for everything HERA has interpreted

A searchable directory of every variant in the HERA database, so you can find prior interpretations without re-running them.

  • Search by gene, HGVS, or protein change
  • Filter by classification — Pathogenic, Likely Pathogenic, VUS, or Benign
  • In-progress queries appear live at the top while they finish processing
  • Open any result to view its complete report
30 May 2026 build 2026.05.30
Feature
+New Gene view — browse the whole HERA corpus by gene

A dedicated gene browser lets you explore every gene HERA has interpreted, organised by its classification mix.

  • Searchable gene list, plus a keyboard-driven command palette for jumping straight to a gene
  • Per-gene classification breakdown from Pathogenic through Benign, shown as a visual mix bar
  • Transcript diagram plotting each variant's position along the gene using UCSC exon structure
  • Click any variant in a gene to open its full interpretation
24 May 2026 build 2026.05.24
Data
+gnomAD Canada frequencies now in every result, with a dashboard linkout

"HERA now includes the gnomAD Canada dataset across all interpretations.

  • Allele frequencies on every variant
  • Ancestry-specific breakdown panel
  • Dashboard linkout per interpretation
20 Apr 2026 build 2026.04.20
Fix
✓Back online — traffic-related issues resolved and the site is stable again