LYFE SCIENCES Project: HERA

Making variant interpretation accessible.

HGVS variant classification driven by ACMG/AMP and VCEP frameworks.

Each variant is checked against the ClinGen expert-panel specification for its gene, criterion by criterion, with the source behind every call.

Every interpretation in the database is free to read — no account needed. A free account adds 5 new interpretations a day, up to 10 a week.

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Transcript accession needs its version — NM_000051.3, not NM_000051 0/150
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LYFE Sciences is an AI system, and it can make mistakes. Criteria may be applied incorrectly, sources may be misread, and a confident-looking classification can still be wrong. Double-check every criterion and its underlying evidence before relying on any call.

Browse variants

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Reading is free and needs no account. New submissions appear here once complete, typically in 5–10 minutes.

Gene Browser

Every gene in the HERA database, by classification mix.

What runs when you press Interpret

Four stages, in order. Each one writes its sources into the report, so you can check the call rather than take it.

01

Normalise

The HGVS string is validated and mapped to genomic coordinates on both GRCh37 and GRCh38. Versionless accessions are rejected here.

02

Gather evidence

Population frequency, splicing predictions, in-silico scores, ClinVar submissions, somatic databases, and the literature for the gene.

03

Apply the right spec

If ClinGen has approved a VCEP specification for the gene, its thresholds are used instead of the generic ACMG defaults.

04

Combine

Criteria are weighted and run through the panel's combining rules to reach a classification, with every step shown.