NM_003537.3:c.244G>C (p.Asp82His) is a missense variant in H3C2, a histone H3 gene recurrently altered in pediatric cancers including glioblastoma.¹ The variant is absent from gnomAD v2.1 and v4.1 population databases (PM2_Supporting).² The variant is not present in COSMIC and does not lie within a statistically significant mutational hotspot. In silico predictions are equivocal: REVEL score is 0.585 and BayesDel is 0.631, both borderline toward pathogenicity, while SpliceAI predicts no splicing impact (max delta 0.08).³ No functional studies, segregation data, de novo reports, or case-control evidence have been identified for this variant. OncoKB reports no variant-specific functional evidence.⁴ A single ClinVar submission from Invitae classifies the variant as uncertain significance; no expert panel or multi-submitter consensus is available.⁵ Only one supporting pathogenic criterion (PM2_Supporting) is met. No benign criteria are met. The evidence is insufficient to classify the variant as pathogenic or benign.⁶