NM_002878.4:c.446T>A (p.Leu149Gln) is a missense variant in exon 5 of RAD51D, a moderate-penetrance breast and ovarian cancer susceptibility gene. Population frequency data from gnomAD v2.1 and v4.1 are unavailable; gnomAD-Canada reports zero observations. The variant cannot be confirmed as absent or rare in population controls.¹ In silico predictions are inconclusive: REVEL (0.434) is intermediate, BayesDel (0.295) is borderline, and SpliceAI predicts no splicing impact (max delta 0.03). Neither PP3 nor BP4 criteria are met.² The variant is reported in ClinVar as Uncertain significance by a single clinical laboratory (Labcorp Genetics/Invitae, SCV007364796) with criteria provided.³ No functional studies, de novo reports, segregation data, case-control studies, or same-residue pathogenic comparators were identified for this variant. No pathogenic or benign criteria are met. The variant is classified as a Variant of Uncertain Significance (VUS) per ACMG/AMP 2015 guidelines.⁴