NM_007294.4:c.4189A>G (p.Arg1397Gly) is a rare missense variant in BRCA1 exon 12, located within the ENIGMA clinically important coiled-coil domain (aa 1391–1424).¹ The variant is absent from gnomAD v2.1 and observed at extremely low frequency in gnomAD v4.1 (2/1,614,142 alleles; grpmax FAF=2.8×10⁻⁷), meeting ENIGMA PM2_Supporting.² In silico predictions are indeterminate: REVEL score is 0.594 (elevated), but the ENIGMA-specified BayesDel no-AF score of 0.153 falls between the BP4 threshold (≤0.15) and PP3 threshold (≥0.28), and SpliceAI predicts no splicing impact (max delta=0.04). Neither PP3 nor BP4 is met.³ No variant-specific functional data, clinical-history likelihood ratios, cosegregation analysis, or case-control data were identified in the ENIGMA VCEP materials or literature reviewed.⁴ With only PM2_Supporting met and no other applicable criteria, the evidence is insufficient to classify this variant beyond Uncertain Significance (VUS) under the ENIGMA BRCA1/2 v1.2.0 framework. The combination of a single supporting-level pathogenic criterion does not reach the Likely Pathogenic threshold.⁵