NM_018062.3:c.580A>G (p.Ile194Val) is a missense variant in exon 8 of FANCL, a Fanconi anemia pathway gene. This variant is present in population databases: 68 of 282,780 alleles in gnomAD v2.1 (AF 0.024%) and 235 of 1,614,080 alleles in gnomAD v4.1 (AF 0.015%), including one homozygous individual in v4.1.¹ Multiple in silico predictors support a benign effect: REVEL score 0.049, BayesDel score -0.583, and SpliceAI max delta score 0.00.² The variant has been reported in ClinVar as Uncertain significance by two clinical laboratories (Labcorp Genetics, Fulgent Genetics) with no expert panel classification.³ No variant-specific functional studies, case-control data, de novo observations, or segregation data are available. The only criterion met is BP4 (supporting benign) based on consistent in silico predictions of no impact.⁴ Applying generic ACMG/AMP 2015 combination rules (PMID:25741868): a single supporting benign criterion (BP4) is insufficient to classify as likely benign. The variant remains a variant of uncertain significance.⁵