NM_000059.4:c.8633-24T>G is an intronic variant in BRCA2 located at position -24 of intron 20. This variant is absent from gnomAD v2.1 (exomes) and v4.1 (genomes) across all populations, meeting PM2 at Supporting strength per ENIGMA BRCA2 VCEP v1.2.0 (pending read depth confirmation at this intronic position).¹ SpliceAI predicts no splicing impact (max delta score 0.00). Combined with its location outside the canonical +/-1,2 splice consensus and beyond the conserved acceptor motif (position -24, beyond -21), this meets BP4_Supporting and BP7_Supporting per ENIGMA BRCA2 VCEP v1.2.0.² The variant is not present in ClinVar and has not been reported in the published literature. No functional assay data, case-control studies, segregation data, or clinical-history likelihood ratios are available for this specific variant.³ Per ENIGMA BRCA1 and BRCA2 VCEP Table 3 combining rules, two Supporting Benign criteria (BP4 + BP7) meet the threshold for Likely Benign. The classification is provisional pending confirmation of gnomAD read depth at position c.8633-24.⁴