NM_001127208.2:c.1413C>T (p.Ser471=) is a synonymous variant in TET2 at extremely low population frequency (gnomAD v2.1 AF=0.00142%, 4/282,248 alleles; v4.1 AF=0.00056%, 9/1,614,034 alleles), meeting PM2 at supporting level.¹ SpliceAI predicts no splicing impact (max delta=0.00), meeting BP7 (supporting benign) for a synonymous variant without predicted splice alteration.² ClinVar contains a single submission classifying this variant as Likely benign (Ambry Genetics, criteria provided), though no expert panel review exists. PS5 and PP5 are not met as the classification is not pathogenic.³ No variant-specific literature, functional studies, de novo observations, or segregation data were identified. Multiple criteria could not be assessed due to absence of evidence. The pathogenic evidence (PM2 supporting) and benign evidence (BP7 supporting_benign) are balanced and of equivalent weight. The variant is classified as a Variant of Uncertain Significance (VUS) per ACMG/AMP 2015 combination rules.⁴