NM_032043.3:c.2085G>A is a synonymous variant in exon 14 of BRIP1 encoding p.Leu695=, predicting no amino acid change. SpliceAI predicts no impact on splicing (max delta score 0.00), supporting a benign interpretation (BP4_Supporting, BP7_Supporting).¹ This variant is absent from gnomAD v2.1, v4.1, and gnomAD-Canada, though absence from population databases does not independently support either benign or pathogenic interpretation for a synonymous variant.² ClinVar classifies this variant as Likely benign (VariationID 530367) based on submissions from three clinical diagnostic laboratories (BP6_Supporting).³ No variant-specific functional data, segregation data, case-control studies, or de novo observations were identified in the literature. No paper reviewed directly mentions NM_032043.3:c.2085G>A. Applying generic ACMG/AMP 2015 classification rules: BP6_Supporting + BP7_Supporting result in Likely Benign (at least two supporting benign criteria).⁴