NM_006182.3:c.1723G>C (p.Gly575Arg) is a missense variant in exon 13 of DDR2. It is extremely rare in population databases, with a global allele frequency of 1.42e-05 in gnomAD v2.1 (4/282,340 alleles) and 5.58e-06 in gnomAD v4.1 (9/1,614,004 alleles), meeting PM2 at supporting strength.¹ REVEL predicts a deleterious score of 0.972, meeting PP3 at supporting strength. BayesDel (0.558) is consistent with this prediction. SpliceAI predicts no splicing impact (max delta = 0.00).² This variant has been reported in ClinVar as Uncertain significance by a single clinical laboratory (Labcorp Genetics, variation ID 4701000). No functional studies, segregation data, de novo observations, or case-control data are available for this variant.³ PVS1 is not applicable as this is a missense variant; PM5 is not applicable as no pathogenic missense variant at the same residue has been identified; BP7 is not applicable as this is not a synonymous variant.⁴