NM_198253.2:c.2781A>G (p.Leu927=) in TERT is a synonymous variant with extremely low population frequency (gnomAD v4.1 AF = 0.00149%, 24/1,613,722 alleles; absent from gnomAD v2.1), meeting PM2 at supporting strength.¹ SpliceAI predicts no splicing alteration (max delta = 0.00), consistent with a silent variant, meeting BP7 at supporting_benign strength.² PVS1 is not met as this synonymous variant does not qualify as a null variant per the ClinGen SVI PVS1 decision framework (PMC6185798). Computational evidence is insufficient for PP3 or BP4. No variant-specific functional studies, case-control data, segregation data, or de novo observations are available. ClinVar reports mixed classifications (Uncertain significance, Likely benign, Benign) from single submitters without expert panel consensus.³ With one supporting pathogenic criterion (PM2) and one supporting benign criterion (BP7), the net evidence weight is indeterminate. This variant is classified as a Variant of Uncertain Significance.⁴