NM_006218.4:c.2016-11G>A is an intronic variant in PIK3CA (intron 13, 11 bases upstream of exon 13). The variant has been observed at low frequency in population databases: 7/262,544 alleles in gnomAD v2.1 (AF 0.00267%) and 71/1,580,816 alleles in gnomAD v4.1 (AF 0.00449%), with no homozygotes.¹ SpliceAI predicts no splicing impact (max delta score = 0.00), suggesting the intronic nucleotide substitution does not create or disrupt a splice site.² This variant has been reported in ClinVar as Likely benign by a single clinical laboratory (Labcorp Genetics, SCV002406335) with review status 'criteria provided, single submitter.' No expert panel classifications are available.³ No functional studies, case reports, segregation data, or de novo observations have been published for this variant. All six associated ClinVar PMIDs are general practice guidelines or background reviews with no variant-specific evidence.⁴ Under the Brain Malformations VCEP (v1.1.0) Tavtigian point framework, no pathogenic criteria are met and no benign criteria are met. The total point score is 0, which falls within the VUS range (0 to 5 points).⁵ Multiple benign-suggesting criteria (BP4, BP7) could not be fully assessed due to missing computational data (varSEAK, MaxEntScan, PhyloP). If additional splicing prediction tools confirm no impact and PhyloP indicates low conservation, this variant may be reclassified toward likely benign.⁶