NM_000059.3:c.3069_3074del (p.Asn1023_Ile1024del) is an in-frame deletion of 6 bp in BRCA2 exon 11, removing two amino acids outside the ENIGMA-defined clinically important functional domains.¹ BP1_Strong is applied: the variant is an in-frame deletion located outside the PALB2 binding domain (aa 10-40) and DNA binding domain (aa 2481-3186), and SpliceAI predicts no splicing impact (delta = 0.00).² No other pathogenic or benign criteria are met. PVS1 is not applicable to this in-frame intra-exonic deletion under ENIGMA Table 4. PM2 is not met as the variant is present in gnomAD population controls (v2.1: 2/281,622 alleles; v4.1: 7/1,613,238). PP3 is not met as the variant is outside functional domains and SpliceAI shows no splicing impact. PP4 and BP5 are not met as the variant is absent from the Li et al. 2020 clinical-history LR table. BA1 and BS1 are not met as gnomAD FAF (1.75e-05) is below both thresholds.³ With a single BP1_Strong criterion and no other criteria met in either direction, the variant does not reach the ENIGMA Likely Benign threshold (requires Strong + Supporting benign, Strong + Moderate benign, or Moderate + Supporting benign). The variant is classified as a Variant of Uncertain Significance.⁴