NM_006180.4:c.2061C>A (p.His687Gln) is a missense variant in exon 19 of NTRK2. It is absent from all population databases (gnomAD v2.1, v4.1, gnomAD-Canada), meeting PM2.¹ No functional studies, case reports, segregation data, de novo observations, or ClinVar classifications are available for this variant. No publications specifically mention NM_006180.4:c.2061C>A.² Computational predictors are discordant: REVEL score 0.77 supports a deleterious effect, but BayesDel score 0.307 is borderline and does not provide a second concordant predictor to meet PP3. SpliceAI predicts no splicing impact (max delta = 0.00).³ With only PM2 (moderate) met, the evidence is insufficient to classify this variant as likely pathogenic or pathogenic under the ACMG/AMP 2015 framework (PMID:25741868). The variant is classified as a Variant of Uncertain Significance (VUS).⁴