NM_015869.4:c.338C>T (p.Pro113Leu) in PPARG is a missense variant absent from ClinVar and present at an extremely low allele frequency of 1.24×10⁻⁶ (2/1,613,144 alleles, 0 homozygotes) in gnomAD v4.1, meeting PM2 at supporting strength (well below 0.1% threshold).¹ REVEL in silico prediction yields a score of 0.74, exceeding the 0.5 threshold for a deleterious call, meeting PP3 at supporting strength. SpliceAI predicts no splicing impact (max delta score 0.00) and BayesDel (0.293) is borderline.² No functional studies, de novo reports, segregation data, or disease-specific cohort data were identified for this variant. PVS1 is not applicable as this is a missense variant (ClinGen SVI PVS1 framework, PMC6185798). All remaining assessed pathogenic and benign criteria were not met.³ With only PM2 (supporting) and PP3 (supporting) met, the evidence is insufficient to reach a Likely Pathogenic or Likely Benign classification under generic ACMG/AMP 2015 combination rules (PMID:25741868). This variant is classified as a Variant of Uncertain Significance (VUS).⁴