NM_001127510.3:c.608A>G (p.Gln203Arg) is a missense variant in APC exon 7. It is absent from gnomAD population databases (PM2_Supporting per APC VCEP).¹ As a missense variant in APC, a gene where primarily truncating variants cause disease, BP1 is met at supporting benign strength. The variant lies at codon 203, outside the excluded β-catenin binding domain region (codons 1021-1035).² No variant-specific functional data, de novo observations, co-segregation data, or case-control data are available. SpliceAI predicts no splicing impact (max delta 0.01). The variant is classified as Uncertain Significance in ClinVar (7 submissions, criteria provided single submitter).³ With one pathogenic supporting criterion (PM2_Supporting) and one benign supporting criterion (BP1), the evidence is balanced, consistent with a classification of Uncertain Significance per the APC VCEP rules for combining criteria.⁴