NM_000044.4:c.455C>T (p.Pro152Leu) in AR is a missense variant in the N-terminal transactivation domain. This variant is extremely rare in population databases: absent from gnomAD v2.1 and gnomAD-Canada, and present in gnomAD v4.1 at an allele frequency of 8.42 × 10⁻⁷ (1/1,187,892 alleles), fulfilling PM2 at supporting strength.¹ In silico predictions are concordantly benign: BayesDel scores -0.012 (benign range) and SpliceAI predicts no splicing alteration (max delta = 0.00), supporting BP4 at supporting level.² One supporting pathogenic criterion (PM2_supporting) and one supporting benign criterion (BP4_supporting) offset each other. The variant is absent from ClinVar, has no functional data, and no literature reports.³ Insufficient evidence to classify as pathogenic or benign. Overall classification: Variant of Uncertain Significance (VUS) per ACMG/AMP 2015 framework.⁴