The ATM c.8315del (p.Gly2772GlufsTer34) variant has been reported in ClinVar with pathogenic and likely pathogenic clinical submissions.¹ This variant is absent from gnomAD v4.1 and gnomAD v2.1, supporting rarity in the general population.² ATM-specific criteria support pathogenic evidence for this truncating variant because p.(Gly2772GlufsTer34) introduces a premature termination codon upstream of the p.Arg3047 threshold used for ATM truncating variants, and ATM loss of function is an established disease mechanism.³ SpliceAI predicts no significant splice impact for this variant, with a maximum delta score of 0.14.⁴