The BRCA2 c.1924_1925insGG (p.(Ser642TrpfsTer3), p.(S642Wfs*3)) variant has not been observed in somatic cancers in COSMIC and has not been reported in ClinVar.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, supporting rarity in population databases.² This early frameshift predicts premature truncation of BRCA2, and the ENIGMA BRCA2 specification supports full PVS1 weight with additional PM5_Strong (PTC) applicability for truncating variants in exon 11.³ SpliceAI predicts no significant splice impact for this variant (max delta score 0.01), which is below the ENIGMA PP3 splice threshold of 0.2 and supports a truncating rather than splice-altering mechanism.⁴