NM_000059.4:c.5661G>A (p.Thr1887=) is a synonymous variant in BRCA2 exon 11. BP1_Strong is met: the variant is a silent substitution outside both ENIGMA-defined clinically important functional domains (PALB2 binding aa 10-40; DNA binding aa 2481-3186), and SpliceAI predicts no splicing impact (max delta = 0.00).¹ This variant is present in gnomAD v4.1 at ultra-low frequency (2/1,612,732 alleles, AF=1.24e-6) in the South Asian and European (non-Finnish) populations. It is absent from gnomAD v2.1. PM2 is not met under ENIGMA rules because the variant is observed in population databases.² The variant has been classified as Likely Benign by the ENIGMA expert panel in ClinVar (Variation ID 51902). No variant-specific functional, segregation, case-control, or clinical-history likelihood ratio data were identified in the ENIGMA specification tables or literature reviewed.³ With only BP1_Strong (1 Strong Benign criterion) met and no other criteria triggered, the variant does not reach the ENIGMA Table 3 threshold for Likely Benign classification based solely on the evidence reviewed here. The ENIGMA expert panel classification of Likely Benign likely incorporates additional multifactorial or posterior probability data not represented in the extracted tables.⁴