NM_000141.4:c.2141A>C (p.Lys714Thr) in FGFR2 is absent from all population databases (gnomAD v2.1, v4.1, gnomAD-Canada), meeting PM2 at supporting strength.¹ No pathogenic or benign criteria beyond PM2_Supporting are met. No functional data, case-control studies, segregation data, de novo reports, or literature evidence were identified for this specific variant.² Under generic ACMG/AMP 2015 final combination rules (PMID:25741868), a single supporting pathogenic criterion (PM2) is insufficient to reach Likely Pathogenic, and no benign criteria are met. The variant is classified as a Variant of Uncertain Significance (VUS).³