NM_000455.5:c.*9G>A is a 3' UTR variant in STK11 located 9 nucleotides downstream of the stop codon. The variant is absent from gnomAD v2.1 (0/109,868 alleles) and present at extremely low frequency in gnomAD v4.1 (9/1,511,712 alleles; AF=0.00006%), supporting application of PM2 at supporting strength.¹ ClinVar lists this variant under ID 387684 with mixed classifications (Likely benign from 3 laboratories, Uncertain significance from 3 laboratories, Benign from 1 laboratory) at 1-star review status, which does not meet the 3-star threshold for PP5 or BP6.² No functional studies, segregation data, de novo observations, case-control data, or phenotype information are available for this variant. No published literature mentions NM_000455.5:c.*9G>A specifically. SpliceAI predicts no splicing impact (max delta score = 0.00), consistent with a benign splicing effect, though insufficient alone to meet BP4.³ With only one pathogenic criterion met at supporting strength (PM2) and no benign criteria met, the evidence is insufficient to classify this variant beyond Variant of Uncertain Significance (VUS) per ACMG/AMP 2015 combination rules.⁴