NM_000546.6:c.-29+102T>G is an intronic variant in TP53 located at position +102 in intron 1. This variant is absent from gnomAD v2.1 and v4.1 population databases, meeting PM2_Supporting per TP53 VCEP specifications (allele frequency <0.00003).¹ SpliceAI predicts no impact on splicing (max delta score 0.00), meeting BP4_Supporting and BP7_Supporting per TP53 VCEP specifications (SpliceAI ≤0.1 for intronic variants).² VCEP Tavtigian point tally: PM2_Supporting (+1), BP4_Supporting (−1), BP7_Supporting (−1) = −1, which falls in the VUS range (−1 to 5).³ Per the VCEP CAVEAT, a final point value of −1 is overridden to Likely Benign when at least two benign evidence codes are applied and PM2_Supporting is the only pathogenic code applied. With BP4_Supporting and BP7_Supporting as the two benign codes, this override applies.⁴ No publications identified for this variant; absent from ClinVar and COSMIC.