The TP53 c.267del (p.Ser90ProfsTer33) variant has been observed in somatic cancers in COSMIC (30 occurrences) and has been reported in ClinVar with Pathogenic and Likely pathogenic germline submissions.¹ This variant is absent from gnomAD v2.1, gnomAD v4.1, and gnomAD-Canada v1.0, placing its allele frequency below the TP53 PM2 threshold of less than 0.00003.² This early frameshift creates a premature stop at codon 122, which is well upstream of the TP53 VCEP p.Lys351 cutoff for predicted nonsense-mediated decay and supports PVS1 at very strong strength.³ SpliceAI predicts no significant splice impact for this variant (max delta score 0.07), and this does not weaken the TP53 null-variant interpretation.⁴