The TP53 c.587G>T (p.Arg196Leu; p.R196L) variant has been observed in somatic cancers in COSMIC (COSV52667931, n=3) and has been reported in ClinVar as a variant of uncertain significance.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, which is below the TP53 VCEP PM2_Supporting population threshold of 0.00003.² In TP53 VCEP-curated functional datasets, Kato transactivation data were partially functional and other eligible assays showed no loss of function, supporting BS3_Supporting rather than PS3.³ TP53 VCEP in silico criteria assign PP3_Moderate for c.587G>T based on aGVGD Class C65 with BayesDel 0.583489; SpliceAI shows no significant splice effect (max delta 0.14), and REVEL is high at 0.933.⁴