NM_000546.6:c.610G>T (p.Glu204Ter) is a nonsense variant in exon 6 of TP53, producing a premature termination codon at position 204 that is predicted to undergo nonsense-mediated decay, satisfying PVS1 at very strong strength per the TP53 VCEP PVS1 flowchart.¹ The variant is absent from all gnomAD population databases (v2.1, v4.1, Canada v1.0), meeting PM2 at supporting strength under the VCEP threshold of <0.00003.² The variant has been observed as a recurrent somatic mutation in COSMIC (n=100, COSV52679869) and is classified as Pathogenic by two clinical laboratories in ClinVar (ClinVarID 977783), consistent with a deleterious truncating effect.³ No proband phenotype data, segregation information, de novo observations, or VAF data are available to support PS2, PS4, PP1, or PP4 scoring under the VCEP point-based system.⁴ The VCEP functional (PS3/BS3) and in silico (PP3/BP4/BP7) criteria are limited to missense variants, in-frame deletions, synonymous variants, and intronic variants by the framework specifications and do not apply to nonsense variants. The truncating consequence is fully captured by PVS1.⁵ Under the Tavtigian point-based classification system used by the TP53 VCEP, PVS1 (very strong = 8 points) plus PM2 (supporting = 1 point) yields a total of 9 points, which falls in the Likely Pathogenic range (6-9 points).⁶