NM_000551.3:c.154G>A (p.Glu52Lys) has a GroupMax filtering allele frequency of 0.08611% (0.0008611) in gnomAD v4.1, which exceeds the VHL VCEP BA1 stand-alone benign threshold of 0.0156% (0.000156).¹ The variant is observed in 107 of 1,583,178 alleles in gnomAD v4.1, including 1 homozygote, with highest frequency in the African/African American population (78/74,388 alleles, 0.1049%).² BA1 as stand-alone benign is independently sufficient to classify the variant as Benign regardless of other evidence criteria.³ BS1 is also met at strong benign level: gnomAD v4 GroupMax FAF 0.0008611 exceeds the VCEP BS1 threshold of 0.0000156.⁴ BP4 is met at supporting benign level: SpliceAI predicts no splicing impact (max delta = 0.00).⁵ The variant was observed in 1-2 VHL families (Olschwang 1998, Gallou 2004) but this does not meet PS4 thresholds and is outweighed by population frequency data.⁶ ClinVar expert panel (ClinGen VHL VCEP) classifies this variant as Benign (VCV000161402).⁷ REVEL score of 0.559 does not meet the VHL VCEP PP3 threshold of ≥0.664. BayesDel score of -0.059 is consistent with a benign prediction.⁸ The variant alters codon 52, which is upstream of the second VHL initiation codon (Met54); only pVHL30 is affected while pVHL19 remains intact. This N-terminal region is outside recognized VHL critical functional domains.⁹