NM_001127208.2:c.3796A>T (p.Asn1266Tyr) is a missense variant in exon 6 of TET2. It is absent from gnomAD population databases (0/1,551,256 alleles) and from ClinVar.¹ The variant meets PM2 at supporting strength due to complete absence from large population cohorts.² In silico predictions are conflicting: REVEL score of 0.707 is indeterminate; BayesDel score of 0.152 does not support pathogenicity; SpliceAI predicts no splicing impact (max delta=0.01). PP3 and BP4 are not met.³ No variant-specific functional studies, de novo reports, segregation data, case-control comparisons, or ClinVar classifications are available for this variant. PS3, PS2/PM6, PP1, PS4, and PP5 are all not met or not assessed.⁴ Under ACMG/AMP 2015 generic rules, one supporting pathogenic criterion (PM2) with no benign criteria yields a classification of Uncertain Significance.⁵