This variant is essentially absent from population databases, with a single heterozygous observation in gnomAD v4.1 (1/1,613,826 alleles; AF = 6.2×10⁻⁷) and no observations in gnomAD v2.1 or gnomAD-Canada, satisfying PM2 at supporting strength.¹ No pathogenic or benign classifications exist in ClinVar. No functional studies, segregation data, de novo observations, or variant-specific publications are available. In silico predictors are conflicting (REVEL 0.638 suggesting possible deleterious effect; BayesDel 0.209 in benign range; SpliceAI delta 0.01).² With only one supporting pathogenic criterion (PM2_supporting) met and no benign criteria met, the variant does not reach the threshold for likely pathogenic, likely benign, or benign classification under generic ACMG/AMP 2015 combination rules. The variant is classified as a Variant of Uncertain Significance (VUS).³