NM_001412.4:c.44G>T (p.Gly15Val) is absent from gnomAD v2.1, v4.1, and gnomAD-Canada population databases (PM2_moderate).¹ The p.Gly15Val residue maps to a statistically significant mutational hotspot (PM1_supporting). Multiple in silico predictors suggest no damaging effect: SpliceAI delta 0.01 and BayesDel -0.06 are both consistent with a neutral effect (BP4_supporting_benign).² One moderate and one supporting pathogenic criterion are countered by one supporting benign criterion. The overall evidence does not meet the threshold for likely pathogenic (requires ≥2 moderate, or 1 moderate + ≥2 supporting) or likely benign (requires ≥2 supporting benign). The variant is classified as a Variant of Uncertain Significance per generic ACMG/AMP 2015 combination rules.³