NM_002253.3:c.2300T>C (p.Ile767Thr) is a missense variant in the KDR gene, located in the transmembrane domain. This variant is absent from gnomAD v2.1 and is extremely rare in gnomAD v4.1 (allele frequency 1.86e-06, 3/1,613,212 alleles), meeting PM2 at moderate strength.¹ The variant is absent from gnomAD-Canada v1.0 and not reported in COSMIC. In silico predictions are equivocal: SpliceAI predicts no splice impact (max delta 0.00), REVEL score is 0.575 (borderline), and BayesDel is -0.004 (neutral). Neither PP3 nor BP4 is met.² The variant has been reported in ClinVar as Uncertain significance by a single clinical laboratory (Ambry Genetics). No submitter has classified it as pathogenic or benign.³ OncoKB classifies KDR I767T as Unknown Oncogenic Effect with no curated functional evidence. No published functional studies or case-level data specific to this variant were identified.⁴ No CSPEC or VCEP framework exists for KDR. Assessment follows generic ACMG/AMP 2015 guidelines.⁵ The single met criterion is PM2 (moderate). No pathogenic criteria at supporting strength or higher are met beyond PM2. Insufficient evidence is available to reach a likely pathogenic or pathogenic classification. Insufficient benign evidence is available to reach a likely benign or benign classification. The variant remains a variant of uncertain significance.