NM_002524.4:c.34G>T (p.Gly12Cys) in NRAS is a missense variant affecting codon 12 in the P-loop (AA 10-17), a critical GTP-binding domain recognized by the RASopathy VCEP.¹ The p.Gly12Cys amino acid change is a well-established pathogenic alteration in NRAS and homologous RAS genes, meeting PS1 at Strong strength.² The variant lies within the P-loop functional domain (PM1, Moderate) and represents a missense change at a codon where other pathogenic missense variants are established (PM5, Moderate).³ The variant is absent from all gnomAD population databases, meeting PM2 at Supporting strength.⁴ REVEL score of 0.773 supports a deleterious effect, meeting PP3 at Supporting strength.⁵ No de novo, cosegregation, case-count, or functional assay data from VCEP-approved platforms were available for this variant; PS2, PS3, PS4, PM6, PP1, BS2, BS4, BP2, and BP5 remain unassessed.