NM_004360.5:c.2053G>A (p.Val685Met) is a missense variant in CDH1 exon 13. The ClinGen CDH1 Expert Panel has classified this variant as Likely benign (ClinVar Variation ID: 133847).¹ The variant is present in gnomAD population databases at low frequency: 4/251,468 alleles in v2.1 (AF 0.00159%) and 24/1,613,720 alleles in v4.1 (AF 0.00149%), with one homozygote reported in v4.1. These frequencies exceed the CDH1 VCEP PM2 threshold of ≤1/100,000 alleles, and the homozygote observation meets BP2_Supporting under the VCEP rules.² SpliceAI predicts no significant splicing impact (max delta score 0.11). In silico protein predictors show borderline scores (REVEL 0.47; BayesDel -0.1394), but per CDH1 VCEP, protein-based computational models are not used for PP3/BP4 assessment.³ No variant-specific functional studies, segregation data, de novo reports, or case-control studies were identified in the reviewed literature. Six full-text papers and 10 additional abstracts were reviewed; none mention NM_004360.5:c.2053G>A or p.Val685Met. One homozygote in gnomAD v4.1 meets CDH1 VCEP BP2_Supporting ('observed in the homozygous state in gnomAD'), providing a single line of benign evidence. No other ACMG criteria are met with the available evidence. Most criteria remain unassessed due to lack of variant-specific functional, segregation, or clinical phenotype data.⁴