NM_005188.3:c.1240C>A (p.Gln414Lys) is a missense variant in CBL, a gene associated with RASopathies and myeloid malignancies through loss-of-function and missense mechanisms.¹ This variant is absent from all large population databases (gnomAD v2.1, v4.1, gnomAD-Canada), meeting PM2 at supporting level.² Multiple lines of computational evidence (BayesDel 0.052, SpliceAI max delta 0.07) predict no damaging impact on the gene product, meeting BP4 at supporting_benign level.³ No functional studies, case reports, segregation data, or literature evidence specific to this variant were identified. The variant is absent from ClinVar and has not been classified by any external source.⁴ With one pathogenic supporting criterion (PM2_Supporting) and one benign supporting criterion (BP4_Supporting), the evidence is insufficient to classify this variant as either pathogenic or benign. The variant is classified as a Variant of Uncertain Significance (VUS) per ACMG/AMP 2015 guidelines.⁵