NM_005933.3:c.7362T>C is a synonymous variant (p.Thr2454=) in KMT2A. KMT2A loss-of-function variants cause Wiedemann-Steiner syndrome (autosomal dominant).¹ This variant is present at extremely low frequency in population databases (gnomAD v2.1: 2/282,756 alleles, AF=7.07e-06; gnomAD v4.1: 2/1,613,960 alleles, AF=1.24e-06), meeting PM2 at supporting level.² SpliceAI predicts no splice impact (max delta=0.0; all four delta scores at 0.0), supporting a benign interpretation under BP4 and BP7.³ No pathogenic in silico predictions are available; REVEL and BayesDel scores were not found for this variant. No computational evidence supports a deleterious effect (PP3 not met).⁴ The variant is absent from ClinVar and no literature reports this specific variant. OncoKB lists classification as 'Unknown Oncogenic Effect' with no supporting evidence.⁵ Applying generic ACMG/AMP 2015 combination rules: PM2 (supporting pathogenic) is outweighed by BP4 (supporting benign) and BP7 (supporting benign), yielding a classification of Likely Benign (2 supporting benign criteria).⁶