NM_005933.3:c.8878G>T (p.Val2960Leu) is a missense variant in exon 27 of KMT2A. This variant is absent from gnomAD v2.1 and v4.1 population databases (PM2_Supporting).¹ Multiple lines of computational evidence predict no deleterious effect: REVEL score 0.178, BayesDel score -0.147545, and SpliceAI max delta 0.00 (BP4_Supporting).² The variant is absent from ClinVar; no pathogenic or benign classification has been assigned by any clinical submitter.³ No functional studies, segregation data, de novo observations, or case reports were identified for this specific variant in the literature. Under generic ACMG/AMP 2015 combination rules, PM2_Supporting and BP4_Supporting are in opposing directions and do not combine to reach a conclusive classification. The variant is classified as a Variant of Uncertain Significance (VUS).⁴