NM_006206.6:c.2524_2526delinsCGA (p.Asp842Arg) in PDGFRA is an in-frame deletion-insertion altering the kinase activation loop residue Asp842, a statistically significant mutational hotspot (PM1). The variant is absent from gnomAD v2.1, v4.1, and gnomAD-Canada population databases (PM2).¹ No other pathogenic or likely pathogenic criteria were met. PVS1 is not applicable (in-frame variant, not a null variant). PS3 functional evidence was not established: although D842R is annotated as Likely Oncogenic by OncoKB and lies in a hotspot, no variant-specific reviewed functional data with citations were identified in the literature packet. No segregation, de novo, in silico, or clinical case data were available.² Under the generic ACMG/AMP 2015 classification framework (PMID:25741868), the combination of two moderate criteria (PM1 + PM2) without additional supporting evidence is insufficient to reach the Likely Pathogenic threshold, which requires ≥3 moderate criteria or ≥2 moderate with ≥2 supporting. The variant is classified as a Variant of Uncertain Significance (VUS).³