NM_012289.4:c.445G>A (p.Glu149Lys) is a missense variant in KEAP1. This variant has been observed in somatic cancers (COSMIC, n=5) but has not been reported in ClinVar and is absent from all population databases (gnomAD v2.1, v4.1, gnomAD-Canada).¹ The variant is absent from gnomAD in all assessed populations, meeting PM2 at supporting strength.² Computational evidence supports a benign effect: BayesDel score of 0.0063572 strongly predicts benign, REVEL score of 0.487 is below the pathogenic threshold, and SpliceAI predicts no splice alteration (max delta 0.00). BP4 is met at supporting strength.³ No functional studies, case-control data, de novo observations, segregation data, or ClinVar classifications are available for this variant. No published literature (PMIDs) was identified that directly mentions NM_012289.4:c.445G>A.⁴ With one supporting pathogenic criterion (PM2) and one supporting benign criterion (BP4), the evidence is insufficient to classify this variant as either likely pathogenic or likely benign under generic ACMG/AMP 2015 rules. The variant is classified as a Variant of Uncertain Significance (VUS).⁵