NM_018062.3:c.355G>A (p.Gly119Arg) is a missense variant in exon 5 of FANCL, a gene associated with autosomal recessive Fanconi anemia. PVS1 is not applicable as this is not a null variant.¹ This variant is extremely rare in population databases, with an allele frequency of 7.96e-06 (0.0008%) in gnomAD v2.1 and 6.21e-07 (0.00006%) in gnomAD v4.1, meeting PM2 at supporting level.² Multiple computational predictors (REVEL 0.104, BayesDel -0.400665, SpliceAI max delta 0.03) concordantly suggest a benign effect, meeting BP4 at supporting level.³ The variant has been reported in ClinVar as uncertain significance by two clinical laboratories (ClinVar ID 653483). No pathogenic or benign assertions exist from expert panels.⁴ Functional data, segregation analysis, de novo observations, case-control studies, and variant-specific literature are all absent for this variant. No publications among the seven reviewed mention NM_018062.3:c.355G>A.⁵ The balanced evidence profile (PM2_supporting vs. BP4_supporting) results in a net score of zero, consistent with a classification of uncertain significance under ACMG/AMP 2015 generic rules.⁶