The DNMT3A c.2116G>C (p.Gly706Arg; p.G706R) variant has not been reported in ClinVar.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, supporting rarity in the general population.² OncoKB classifies this variant as Likely Oncogenic with a likely loss-of-function biological effect, but the available evidence does not provide a well-established variant-specific functional study result sufficient for ACMG PS3 or BS3.³ Computational evidence supports a deleterious protein effect, with REVEL 0.971, while SpliceAI predicts no significant splice impact with a maximum delta score of 0.04.⁴