The PALB2 c.338C>T (p.Pro113Leu) variant has been reported in ClinVar, where the ClinGen Hereditary Breast, Ovarian and Pancreatic Cancer expert panel classified it as uncertain significance, with additional submissions of uncertain significance and likely benign.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, placing its observed frequency below the PALB2 PM2_Supporting threshold of 1/300,000 (0.000333%).² SpliceAI predicts no splice impact with a max delta score of 0.00, and missense predictors are low (REVEL 0.012; BayesDel -0.722131); however, the PALB2 expert specification does not use PP3 or BP4 for missense prediction and applies BP1_Supporting to all missense variants.³