NM_024675.4:c.928A>G (p.Ser310Gly) is a missense variant in PALB2 exon 4. Under the ClinGen Hereditary Breast, Ovarian and Pancreatic Cancer Expert Panel specifications for PALB2 v1.2.0, missense pathogenic variation is not yet confirmed as a mechanism of disease.¹ The variant is present in gnomAD v4.1 at a grpmax filtering allele frequency of 0.01511% (206/1,614,002 alleles), exceeding the PALB2 VCEP BS1 threshold of >0.01%, meeting BS1 at Strong strength.² BP1 (Supporting benign) is met per VCEP rule that applies to all PALB2 missense variants, as true missense pathogenic variants in PALB2 are thought to be exceedingly rare.³ The gnomAD v4.1 frequency (0.01511%) does not reach the BA1 threshold (>0.1%) or the PM2 threshold (<=0.000333%). In silico predictions (SpliceAI max delta=0.02, REVEL=0.034, BayesDel=-0.732) are not used under this VCEP for missense variants per PP3/BP4 rules.⁴ No case-control studies, co-segregation data, or Fanconi Anemia biallelic observations were available to assess PS4, PP1, BS2, or BS4.⁵ Applying the PALB2 VCEP/ACMG combination rules: one Benign Strong criterion (BS1) plus one Benign Supporting criterion (BP1) is consistent with a Likely Benign classification per Rule 18.⁶