The PALB2 c.968C>T (p.Ala323Val) variant has not been observed in somatic cancers in COSMIC and has been reported in ClinVar as a variant of uncertain significance.¹ This variant is absent from gnomAD v2.1 and gnomAD v4.1, so its population frequency is below the PALB2 PM2_Supporting threshold of 0.000333%.² SpliceAI predicts no significant splice impact for this variant, with a maximum delta score of 0.03, which is below the PALB2 PP3 splice threshold of 0.2.³ As a missense variant in PALB2, this change meets BP1 because pathogenic missense variation is considered uncommon in this gene under the PALB2 specifications.⁴