NM_033084.4:c.70A>G (p.Arg24Gly) is a missense variant in exon 3 of FANCD2. The variant is extremely rare in population databases (gnomAD v4.1 AF 3.1e-06, 5/1,612,676 alleles, 0 homozygotes; absent from gnomAD v2.1 and gnomAD-Canada), meeting PM2 at supporting level.¹ Multiple lines of computational evidence (REVEL 0.023, BayesDel -0.631, SpliceAI max delta 0.08) are concordant for a benign interpretation, meeting BP4 at supporting benign level.² The variant has been reported in ClinVar (VariationID 1692057) by a single submitter (Sema4) as uncertain significance; no reputable source has classified it as pathogenic or benign.³ No functional studies, segregation data, de novo observations, case-control data, or variant-specific literature evidence were identified for this variant.⁴ Five ClinVar-associated PMIDs were reviewed; none contained variant-specific evidence for NM_033084.4:c.70A>G.⁵ With one supporting pathogenic criterion (PM2) and one supporting benign criterion (BP4) in conflict, and no additional criteria met, the variant is classified as Uncertain Significance (VUS) per generic ACMG/AMP 2015 combination rules.⁶