NM_152756.4:c.3667G>T (p.Asp1223Tyr) is a missense variant in RICTOR. It is absent from gnomAD v2.1, v4.1, and gnomAD-Canada population databases (PM2_Supporting).¹ This variant is absent from ClinVar; no reputable source has classified it as pathogenic or benign. It is absent from COSMIC and does not lie in a statistically significant mutational hotspot.² Computational predictors are equivocal: REVEL score is 0.471 (intermediate, below the typical 0.5 pathogenicity threshold), BayesDel is 0.102, and SpliceAI predicts no significant splice impact (max delta 0.05). These do not meet PP3 or BP4 thresholds.³ No variant-specific functional studies, segregation data, de novo reports, or case-control data are available. OncoKB reports Unknown Oncogenic Effect.⁴ Only one criterion is met: PM2 (supporting). Under the generic ACMG/AMP 2015 classification framework (PMID:25741868), a single supporting criterion is insufficient to classify this variant as likely pathogenic or likely benign. This variant is classified as a Variant of Uncertain Significance (VUS).⁵