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LYFE SCIENCES
Project: HERA
NM_004985.4:c.24A>G
p.Val8=  ·  KRAS
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Classification rationale
1

The KRAS c.24A>G (p.Val8=) variant has been reported in ClinVar with an expert panel classification of likely benign, with additional benign and likely benign clinical laboratory submissions.

clinvar ↗
2

This variant is present in population databases at a frequency above the KRAS VCEP benign thresholds, with grpmax filtering allele frequencies of 0.0402% in gnomAD v2.1 and 0.056632% in gnomAD v4.1, exceeding the BS1 threshold of 0.025% and the BA1 threshold of 0.05% in v4.1.

cspec ↗ gnomad_v2 ↗ gnomad_v4 ↗
3

SpliceAI predicts no significant splice impact for this variant, with a maximum delta score of 0.02, supporting no expected clinically meaningful effect on splicing.

spliceai ↗
Applied criteria
Met
Not met
Not assessed
N/A
Very strong
Strong
Moderate
Supporting
Pathogenic evidence
PVS
PVS1
PS
PS1
PS2
PS3
PS4
PM
PM1
PM2
PM3
PM4
PM5
PM6
PP
PP1
PP2
PP3
PP4
PP5
Benign evidence
BA
BA1
BS
BS1
BS2
BS3
BS4
BP
BP1
BP2
BP3
BP4
BP5
BP6
BP7
PVS1
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Rationale
Select a criterion to inspect its explanation.
Evidence used
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Gaps remaining
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Rule
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Publications
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Research and evidence
gnomAD v2.1 evidence
v2.1
gnomAD v4.1 evidence
v4.1
01
Population
gnomAD v2.1This variant is present in gnomAD v2.1 (AF= 0.000253604; MAF= 0.02536%, 71/279964 alleles, homozygotes = 0) and has highest observed frequency in the European (non-Finnish) population (AF= 0.000509524; MAF= 0.05095%, 65/127570 alleles, homozygotes = 0); grpmax FAF= 0.000402.
gnomAD v4.1This variant is present in gnomAD v4.1 (AF= 0.000460165; MAF= 0.04602%, 742/1612464 alleles, homozygotes = 0) and has highest observed frequency in the European (non-Finnish) population (AF= 0.000603834; MAF= 0.06038%, 712/1179132 alleles, homozygotes = 0); grpmax FAF= 0.00056632.
gnomAD v2 ↗ gnomAD v4 ↗
ClinVar evidence
02
ClinVar
This variant has been reported in ClinVar as Likely benign (11 clinical laboratories) and as Benign (3 clinical laboratories) and as Likely benign by ClinGen RASopathy Variant Curation Expert Panel (expert panel).
ClinVar ↗
Functional evidence
03
Functional
OncoKB: Unknown Oncogenic Effect
OncoKB identified curated literature and non-variant-specific oncogenicity context for review; listed oncogenicity label: Unknown Oncogenic Effect.
OncoKB ↗
In silico evidence
04
In silico
SpliceAI predicts no significant splice impact for this variant (max delta score = 0.02).
SpliceAI ↗
COSMIC evidence
05
COSMIC
This variant does not lie in a statistically significant hotspot. This variant has previously been reported in somatic cancers (COSMIC; COSV99778613, n = 1 times).
COSMIC ↗
Cancer hotspots evidence
06
Cancer hotspots Not found
This variant does not lie in a statistically significant hotspot.
ResidueV8
Hotspots ↗