NM_007194.4:c.1095+19G>A is an intronic variant in CHEK2 located at position +19 in intron 10. Computational evidence predicts no splicing impact: SpliceAI maximum delta score is 0.00 across all categories, consistent with a neutral intronic change (BP4_Supporting).¹ A homozygous individual for this variant is observed in gnomAD v4.1, which is inconsistent with a highly penetrant autosomal dominant cancer predisposition variant (BS2_Supporting).² ClinVar reports this variant as Likely benign by 9 clinical laboratories and Benign by 3 clinical laboratories (Variation ID: 371849), providing reputable source support for a benign interpretation (BP6_Supporting).³ The variant is observed at population frequencies of 0.017% (gnomAD v2.1) and 0.012% (gnomAD v4.1) with the highest subpopulation frequency of 0.237% in the Middle Eastern population (gnomAD v4.1), which approaches but does not exceed the BS1 threshold of 0.3%.⁴ No functional studies, segregation data, case-control enrichment, or variant-specific publications were identified for this variant. Three benign supporting criteria (BP4, BP6, BS2) are met. Under generic ACMG/AMP 2015 combination rules (PMID:25741868), two or more benign supporting criteria support a Likely Benign classification.⁵