NM_000546.5:c.612_623del (p.Glu204_Asp207del) is an in-frame deletion of 12 nucleotides in exon 6 of TP53, removing four amino acids (204-207) within the DNA-binding core domain (residues 102-292). The variant is absent from gnomAD v2.1, v4.1, and gnomAD-Canada (0 alleles across all population databases), meeting PM2_Supporting under the TP53 VCEP (AF < 0.00003).¹ The variant is absent from ClinVar and has not been previously classified by any diagnostic laboratory or expert panel.² The variant is not a null variant (nonsense, frameshift, or canonical splice) and is not addressed by the TP53 VCEP PVS1 decision tree, which covers only truncating and exon-level deletion variants. PVS1 is not applicable.³ No variant-specific functional data are available. The VCEP Functional-worksheet catalogs single amino acid substitutions and deletions but does not include the 4-amino-acid deletion p.Glu204_Asp207del. Two reviewed publications (PMID:11900253, PMID:8023157) discuss p53 structure and function at the gene level but do not mention this specific variant.⁴ Several criteria (PS2, PS4, PP1, PP4, BS2, BS4) could not be assessed due to absence of proband phenotype, family, or segregation data. Multiple VCEP criteria (PM4, PM6, PP2, PP5, BP1, BP2, BP3, BP5, BP6) are explicitly marked as Not Applicable under the TP53 VCEP v2.4 framework.⁵ The only applicable and met criterion is PM2_Supporting (absent from population databases). All other assessable criteria are either not applicable, not met, or not assessed due to insufficient data.⁶