NM_177438.2:c.3334A>G (p.Asn1112Asp) is a missense variant in exon 21 of DICER1, located outside the RNase IIIb catalytic domain (p.Y1682-p.S1846) and not at a metal ion-binding residue.¹ This variant is present in gnomAD at a frequency exceeding the DICER1 VCEP threshold for rarity. In the East Asian population, the allele frequency is 0.098% (gnomAD v2.1, 18/18,382 alleles) and 0.198% (gnomAD v4.1, 89/44,880 alleles), meeting BS1 at strong strength (VCEP threshold: >0.03%).² Computational predictions uniformly support a benign interpretation: REVEL score 0.109 (below BP4 threshold of <0.500), SpliceAI max delta 0.09 (no splicing impact), and BayesDel score -0.562 (benign). BP4 is met at supporting strength.³ In ClinVar, this variant has been classified as Likely benign by three clinical laboratories (Ambry Genetics, Labcorp/Invitae, Illumina) and as Uncertain significance by one (GeneDx). No expert panel has reviewed this variant. The ITMI submission derived from a reference population cohort (Bodian et al. 2014), consistent with a benign population variant.⁴ No functional studies, segregation data, de novo observations, or tumor testing data are available for this variant. No pathogenic comparator variants exist at codon 1112 for PM5 application. The variant falls outside characterized functional domains, so PM1 does not apply. Applying the DICER1 VCEP v1.4 Tavtigian point-based classification framework: BS1_Strong (-4 points) + BP4_Supporting (-1 point) = -5 points. This falls within the Likely Benign range (>= -6 and <= -2).⁵ Final classification: Likely Benign.