NM_004360.5:c.48+6_48+7delinsTT is an intronic variant affecting positions +6 and +7 of CDH1 intron 1, outside the canonical splice consensus sequence.¹ This variant is absent from gnomAD v2.1 and v4.1 population databases, meeting the CDH1 VCEP PM2_Supporting criterion (≤1 in 100,000 alleles).² SpliceAI predicts no significant splice impact (max delta score 0.06). However, only SpliceAI data is available among the seven splicing predictors specified by the CDH1 VCEP, which is insufficient to meet PP3 or BP4 thresholds requiring at least three concordant predictors.³ No RNA functional studies, de novo occurrence data, case-control data, co-segregation data, or family studies meeting HDGC criteria were identified for this variant.⁴ This variant has been reported in ClinVar as Likely benign (VariationID 136068) with a 1-star review status (criteria provided, single submitter). The ClinVar-associated publications are clinical practice guidelines and policy statements that do not provide variant-specific evidence.⁵ With only PM2_Supporting met and no other pathogenic or benign criteria satisfied, this variant is classified as a Variant of Uncertain Significance under the CDH1 VCEP framework (v3.1). The ClinVar Likely benign classification has low evidentiary weight (1-star) and cannot independently drive a benign classification.⁶